Safety Pharmacology and PD models

Safety Pharmacology and PD models

– Safety Pharmacology performed since 1995

– Core battery studies to support Phase I clinical trials

– Designed as standalone investigations or included on toxicology studies

– Includes Cardiovascular (CV) assessment

Anaesthetized and Telemetry (implanted and non-invasive)

– Irwin test

– Functional Observational Battery (FOB)

– Supplementary studies: renal function, GI transit/emptying time

– Research models

CNS, CV, respiratory, GI, renal, inflammation, metabolism